Chromosome Changes in Human Non Hodgkin’s Lymphoma (nhl)
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چکیده
Non Hodgkin’s Lymphoma (NHL) or Lymphoma is a cancer that affects the lymphocytes of the immune system and present as a solid of lymphoid cell mass. Genetic disorder is one of the important factors for development NHL .The present study of bone marrow sample includes 65 NHL patients (46 male and 19 female) Chromosome analysis demonstrated that about 73.84 % of metaphase plate of NHL patients showed numerical aberration, i.e Polyploidy observed in 26 cases and 22 cases showed hypoploidy. The high frequency of chromosomal aberration indicates chromosomal instability that invariable associated with malignancy. The results of the present preliminary investigation will provide a basis for future diagnosis, prognosis and curability of NHL.
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تاریخ انتشار 2012